Article
Lifestyle and Reproductive Factors and Ovarian Cancer Risk by p53 and MAPK Expression.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2018
Harris Holly R, Rice Megan S, Shafrir Amy L, Poole Elizabeth M, Gupta Mamta, Hecht Jonathan L, Terry Kathryn L, Tworoger Shelley S
Abstract excerpt
Background: One model of ovarian cancer development model divides tumors into two types. Type I tumors are characterized by KRAS and BRAF mutations, which can activate mitogen-activated protein kinase (MAPK). Type II tumors are characterized by tubal precursor lesions with p53 mutations. We evaluated the association between lifestyle and reproductive factors and risk of ovarian cancer defined by p53 and MAPK...
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