Article
Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells.
European journal of medicinal chemistry - 1 Jan 2018
Ramisetti Srinivasa Rao, Pandey Manoj K, Lee Sang Y, Karelia Deepkamal, Narayan Satya, Amin Shantu, Sharma Arun K
Abstract excerpt
A series of novel thio- and seleno-barbituric acid derivatives were synthesized by varying the substituents at N1 and N3 (ethyl, methyl, allyl, and phenyl), and C5 tethered with dienyl and trienyl moieties attached to substituents such as phenyl, 2-furanyl, 2-thiophenyl, 1-naphthyl, and 3-pyridyl. The cytotoxic potential of these derivatives was evaluated by using MTT assay against melanoma cell lines expressing...
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