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Pediatric glioblastoma cells inhibit neurogenesis and promote astrogenesis, phenotypic transformation and migration of human neural progenitor cells within cocultures.

Experimental cell research - 1 Jan 2018

Farrell Kurt, Mahajan Gautam, Srinivasan Parthasarathy, Lee Moo-Yeal, Kothapalli Chandrasekhar R

Abstract excerpt

Neural progenitor cell (NPC) fate is influenced by a variety of biological cues elicited from the surrounding microenvironment and recent studies suggest their possible role in pediatric glioblastoma multiforme (GBM) development. Since a few GBM cells also display NPC characteristics, it is not clear whether NPCs transform to tumor cell phenotype leading to the onset of GBM formation, or NPCs migrate to...

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Identifiers

PMID: 29129566
DOI: 10.1016/j.yexcr.2017.11.013
PMCID: PMC5741502

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