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Article

Mitochondrial myopathy with autophagic vacuoles in patients with the m.8344A>G mutation.

Journal of clinical pathology - 1 Aug 2013

Yuan Jun-Hui, Sakiyama Yusuke, Higuchi Itsuro, Inamori Yukie, Higuchi Yujiro, Hashiguchi Akihiro, Higashi Keiko, Yoshimura Akiko, Takashima Hiroshi

Abstract excerpt

BACKGROUND AND AIMS: In mitochondrial myopathy, autophagy is presumed to play an important role in mitochondrial dysfunction. Rimmed vacuoles (RVs), a sign of autophagy, can be seen as a secondary phenomenon in muscle ragged-red fibres (RRFs), whereas the uncommon presentation is that some fibres contain RVs, but without any mitochondrial abnormalities. To investigate the pathogenesis beneath this pathological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23559353
DOI: 10.1136/jclinpath-2012-201431

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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