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miRNA profiling of NurOwn®: mesenchymal stem cells secreting neurotrophic factors

7 Nov 2017

Abstract excerpt

BACKGROUND: MSC-NTF cells are Mesenchymal Stromal Cells (MSC) induced to express high levels of neurotrophic factors (NTFs) using a culture-medium based approach. MSC-NTF cells have been successfully studied in clinical trials for Amyotrophic Lateral Sclerosis (ALS) patients. MicroRNAs (miRNA) are short non-coding RNA molecules that coordinate post-transcriptional regulation of multiple gene targets. The purpose...

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PMID: 29116031
DOI: 10.1186/s13287-017-0692-1

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