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Article

CXCR4/CXCR7/CXCL12 axis promotes an invasive phenotype in medullary thyroid carcinoma.

British journal of cancer - 5 Dec 2017

Werner Thomas A, Forster Christina M, Dizdar Levent, Verde Pablo E, Raba Katharina, Schott Matthias, Knoefel Wolfram T, Krieg Andreas

Abstract excerpt

BACKGROUND: Medullary thyroid carcinoma (MTC) is a rare and challenging endocrine malignancy. Once spread, the therapeutic options are limited and the outcome poor. For these patients, the identification of new druggable biological markers is of great importance. Here, we investigated the prognostic and biological role of the C-X-C chemokine receptors type 4 and 7 (CXCR4/7) in MTC. METHODS: Eighty-six MTC and...

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Identifiers

PMID: 29112684
DOI: 10.1038/bjc.2017.364
PMCID: PMC5729476

Genes

CXCR4
CXCL12

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