Article
The influence of immunosuppressants on direct-acting antiviral therapy is dependent on the hepatitis C virus genotype.
Transplant infectious disease : an official journal of the Transplantation Society - 1 Feb 2018
Frey Alexandra, Piras-Straub Katja, Walker Andreas, Timm Jörg, Gerken Guido, Herzer Kerstin
Abstract excerpt
BACKGROUND: Direct-acting antivirals (DAAs) have substantially increased sustained virological response rates after liver transplantation, with improved tolerance compared to interferon-based therapy. The influence of immunosuppressive agents on the efficacy of DAAs has not been clarified. METHODS: Subgenomic hepatitis C virus (HCV) replicons for genotype (GT) 1b, 2b, 3a, and 4a were treated with the mammalian...
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