Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pegylated IFN-α suppresses hepatitis C virus by promoting the DAPK-mTOR pathway.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2016

Liu Wei-Liang, Yang Hung-Chih, Hsu Ching-Sheng, Wang Chih-Chiang, Wang Tzu-San, Kao Jia-Horng, Chen Ding-Shinn

Abstract excerpt

Death-associated protein kinase (DAPK) has been found to be induced by IFN, but its antiviral activity remains elusive. Therefore, we investigated whether DAPK plays a role in the pegylated IFN-α (peg-IFN-α)-induced antiviral activity against hepatitis C virus (HCV) replication. Primary human hepatocytes, Huh-7, and infectious HCV cell culture were used to study the relationship between peg-IFN-α and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Death-Associated Protein Kinases
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Hepatocytes

Share to Interferon-alpha

Share to p21-Activated Kinases

Share to Polyethylene Glycols

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 27930338
DOI: 10.1073/pnas.1618517114
PMCID: PMC5187687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pegylated IFN-α suppresses hepatitis C virus by promoting the DAPK-mTOR pathway.PMID 27930338Read ↗

mTOR Signaling: Roles in Hepatitis B Virus Infection and Hepatocellular CarcinomaSemantic proximity Read ↗

Regulation of Interferon-Dependent mRNA Translation of Target GenesSemantic proximity Read ↗

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E PathwaySemantic proximity Read ↗

mTORC1 restricts hepatitis C virus RNA replication through ULK1-mediated suppression of miR-122 and facilitates post-replication eventsSemantic proximity Read ↗

Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.Semantic proximity Read ↗

The Multifunctional Role of mTOR in Innate Immunity: Implications for Transplant ImmunitySemantic proximity Read ↗

4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N‐Ras proto‐oncogenes in miceSemantic proximity Read ↗

Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized miceSemantic proximity Read ↗

Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation.Semantic proximity Read ↗

The Changing Role of mTOR Kinase in the Maintenance of Protein Synthesis during Human Cytomegalovirus InfectionSemantic proximity Read ↗

Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway.Semantic proximity Read ↗

The influence of immunosuppressants on direct-acting antiviral therapy is dependent on the hepatitis C virus genotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.