Article
The developmental transcription factor IRF6 attenuates ABCG2 gene expression and distinctively reverses stemness phenotype in nasopharyngeal carcinoma.
Cancer letters - 1 Sept 2018
Xu Liang, Huang Tie-Jun, Hu Hao, Wang Meng-Yao, Shi Si-Mei, Yang Qin, Lin Fen, Qiang Yuan-Yuan, Mei Yan, Lang Yan-Hong, Li Chang-Zhi, Peng Li-Xia, Zheng Li-Sheng, Huang Jia-Ling, Li Xin-Jian, Zhang Shi-Jun, Qian Chao-Nan, Huang Bi-Jun
Abstract excerpt
Nasopharyngeal carcinoma (NPC), which originates from the nasopharynx, is highly prevalent in Southern China and Southeast Asia, and more than 90% of all NPCs are non-keratinizing undifferentiated cells or poorly differentiated squamous cells. Cancer stem cells (CSCs) are capable of self-renewal and have differentiation potential. These properties form the basis of cancer initiation, development, and...
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