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Article

Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells.

Cancer letters - 28 Jan 2018

Kumar Sandeep, Inigo Joseph R, Kumar Rahul, Chaudhary Ajay K, O'Malley Jordan, Balachandar Srimmitha, Wang Jianmin, Attwood Kristopher, Yadav Neelu, Hochwald Steven, Wang Xinjiang, Chandra Dhyan

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for this outcome. Nimbolide (NL), a triterpenoid obtained from Azadirachta indica, exhibits anticancer properties in various cancer including PDAC cells. However, the underlying mechanism of this anticancer agent...

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Identifiers

PMID: 29107110
DOI: 10.1016/j.canlet.2017.10.029
PMCID: PMC5706561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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