Article
Tracking and responding to an outbreak of tuberculosis using MIRU-VNTR genotyping and whole genome sequencing as epidemiological tools.
Journal of public health (Oxford, England) - 1 Jun 2018
Black Anne T, Hamblion Esther L, Buttivant Helen, Anderson Sarah R, Stone Madeline, Casali Nicola, Drobniewski Francis, Nwoguh Francisca, Marshall Ben G, Booth Linda
Abstract excerpt
Background: We describe an outbreak that contributed to a near doubling of the incidence of tuberculosis in Southampton, UK. We examine the importance of 24 locus mycobacterial interspersed repetitive unit variable number tandem repeat (MIRU-VNTR) genotyping in its identification and management and the role of whole genome sequencing (WGS) in tracing the spread of the strain. Methods: Outbreak cases were defined...
Topics
- Adolescent
- Adult
- Child
- Child, Preschool
- Disease Outbreaks
- Female
- Genotype
- Humans
- Infant
- Male
- Mycobacterium tuberculosis