Article
Genetic Variations of Melatonin Receptor Type 1A are Associated with the Clinicopathologic Development of Urothelial Cell Carcinoma.
International journal of medical sciences - 1 Jan 2017
Lin Yung-Wei, Wang Shian-Shiang, Wen Yu-Ching, Tung Min-Che, Lee Liang-Ming, Yang Shun-Fa, Chien Ming-Hsien
Abstract excerpt
Melatonin counteracts tumor occurrence and tumor cell progression in several cancer types in vitro and in vivo. It acts predominantly through its melatonin receptor type 1A (MTNR1A), and genetic variations of MTNR1A affect the susceptibility several diseases and cancer. The purpose of this study was to explore the effect of MTNR1A gene polymorphisms on the susceptibility to and clinicopathological characteristics...
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