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Article

Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder.

Journal of psychiatric research - 1 Jan 2018

Grünblatt Edna, Marinova Zoya, Roth Alexander, Gardini Elena, Ball Juliane, Geissler Julia, Wojdacz Tomasz K, Romanos Marcel, Walitza Susanne

Abstract excerpt

While genetic variants have been reported to be associated with obsessive-compulsive disorder (OCD), the small effect sizes suggest that epigenetic mechanisms such as DNA methylation may also be relevant. The serotonin transporter (SLC6A4) gene has been extensively investigated in relation to OCD, since serotonin reuptake inhibitors are the pharmacological treatment of choice for the disorder. The current study...

Topics

Adolescent
Adult
Case-Control Studies
Child
DNA Methylation
Epigenesis, Genetic
Female
Genetic Association Studies
Genetic Loci
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hydrocortisone

Introns

Male

Obsessive-Compulsive Disorder

Photoperiod

Pilot Projects

Promoter Regions, Genetic

Source

Identifiers

PMID: 29102815
DOI: 10.1016/j.jpsychires.2017.10.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29102815-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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