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Article

Urine-derived podocytes-lineage cells: A promising tool for precision medicine in Alport Syndrome.

Human mutation - 1 Feb 2018

Daga Sergio, Baldassarri Margherita, Lo Rizzo Caterina, Fallerini Chiara, Imperatore Valentina, Longo Ilaria, Frullanti Elisa, Landucci Elisa, Massella Laura, Pecoraro Carmine, Garosi Guido, Ariani Francesca, Mencarelli Maria Antonietta, Mari Francesca, Renieri Alessandra, Pinto Anna Maria

Abstract excerpt

Alport Syndrome (ATS) is a rare genetic disorder caused by collagen IV genes mutations, leading to glomerular basement membrane damage up to end-stage renal disease. Podocytes, the main component of the glomerular structure, are the only cells able to produce all the three collagens IV alpha chains associated with ATS and thus, they are key players in ATS pathogenesis. However, podocytes-targeted therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29098738
DOI: 10.1002/humu.23364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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