Article
Generation of an urine-derived induced pluripotent stem cell line from a 5-year old X-linked Alport syndrome (X-LAS) patient.
Stem cell research - 1 Dec 2020
Guo Xiaoling, Ji Weiping, Niu Chao, Ding Yinjuan, Chen Zhanguo, Chen Congde, Tong Hongfei, Han Zhao, Chu Maoping
Abstract excerpt
The gene mutations of the collagen type IV alpha 5 chain (COL4A5) can lead to the inherited haematuria to end-stage renal disease X-linked Alport syndrome (X-LAS). The urine cells of a 5-year-old male X-LAS patient carrying a hemizygous COL4A5 gene mutation p.G1433V (c.4298G>T) were reprogrammed to induced pluripotent stem cells (iPSCs) with Sendai virus reprogramming kit containing OCT4, SOX2, c-MYC, and KLF4...
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