Article
A functional polymorphism at miR-491-5p binding site in the 3'-UTR of MMP-9 gene confers increased risk for atherosclerotic cerebral infarction in a Chinese population.
Atherosclerosis - 1 Feb 2013
Yuan Mei, Zhan Qiong, Duan Xiaomei, Song Bingxin, Zeng Sian, Chen Xiaoping, Yang Qidong, Xia Jian
Abstract excerpt
BACKGROUND: and purpose: Matrix metalloproteinases 9 (MMP-9) has been reported to play a critical role in the pathophysiology of atherosclerotic cerebral infarction (ACI). Here we assessed association of MMP-9 polymorphisms with ACI susceptibility and the function of SNPs through microRNA mediated regulation. METHODS: Genotyping was performed using MALDI-TOF mass spectrometry. Reporter gene plasmids with the...
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