Acquisition of the Phosphate Transporter NptA Enhances Staphylococcus aureus Pathogenesis by Improving Phosphate Uptake in Divergent Environments

Abstract excerpt

ABSTRACT During infection, pathogens must obtain all inorganic nutrients, such as phosphate, from the host. Despite the essentiality of phosphate for all forms of life, how Staphylococcus aureus obtains this nutrient during infection is unknown. Differing from Escherichia coli , the paradigm for bacterial phosphate acquisition, which has two inorganic phosphate (P i ) importers, genomic analysis suggested that S....

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