Article
Circulating Tumor Cells from Different Vascular Sites Exhibit Spatial Heterogeneity in Epithelial and Mesenchymal Composition and Distinct Clinical Significance in Hepatocellular Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2018
Sun Yun-Fan, Guo Wei, Xu Yang, Shi Yin-Hong, Gong Zi-Jun, Ji Yuan, Du Min, Zhang Xin, Hu Bo, Huang Ao, Chen George G, Lai Paul B S, Cao Ya, Qiu Shuang-Jian, Zhou Jian, Yang Xin-Rong, Fan Jia
Abstract excerpt
Purpose: The spatial heterogeneity of phenotypic and molecular characteristics of CTCs within the circulatory system remains unclear. Herein, we mapped the distribution and characterized biological features of CTCs along the transportation route in hepatocellular carcinoma (HCC).Experimental Design: In 73 localized HCC patients, blood was drawn from peripheral vein (PV), peripheral artery (PA), hepatic veins...
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