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Article

Methods for Characterizing Disease-Associated ATP-Sensitive Potassium Channel Mutations.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Kandasamy Balamurugan, Shyng Show-Ling

Abstract excerpt

The ATP-sensitive potassium (KATP) channel formed by the inwardly rectifying potassium channel Kir6.2 and the sulfonylurea receptor 1 (SUR1) plays a key role in regulating insulin secretion. Genetic mutations in KCNJ11 or ABCC8 which encode Kir6.2 and SUR1 respectively are major causes of insulin secretion disorders: those causing loss of channel function lead to congenital hyperinsulinism, whereas those causing...

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Source

Identifiers

PMID: 29058186
DOI: 10.1007/978-1-4939-7362-0_8

Genes

ABCC8
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methods for Characterizing Disease-Associated ATP-Sensitive Potassium Channel Mutations.PMID 29058186Read ↗

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