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Article

Genomic landscape associated with potential response to anti-CTLA-4 treatment in cancers.

Nature communications - 19 Oct 2017

Ock Chan-Young, Hwang Jun-Eul, Keam Bhumsuk, Kim Sang-Bae, Shim Jae-Jun, Jang Hee-Jin, Park Sarang, Sohn Bo Hwa, Cha Minse, Ajani Jaffer A, Kopetz Scott, Lee Keun-Wook, Kim Tae Min, Heo Dae Seog, Lee Ju-Seog

Abstract excerpt

Immunotherapy has emerged as a promising anti-cancer treatment, however, little is known about the genetic characteristics that dictate response to immunotherapy. We develop a transcriptional predictor of immunotherapy response and assess its prediction in genomic data from ~10,000 human tissues across 30 different cancer types to estimate the potential response to immunotherapy. The integrative analysis reveals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29051489
DOI: 10.1038/s41467-017-01018-0
PMCID: PMC5648801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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