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Applied multiplex allele specific PCR to detect second-line drug resistance among multidrug-resistant tuberculosis in China.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2017

Liang Ya-Ping, Chen Yan, Xiao Tong-Yang, Xia Qiang, Liu Hai-Can, Zhao Xiu-Qin, Zeng Chun-Yan, Zhao Li-Li, Wan Kang-Lin

Abstract excerpt

Rapid detection of resistance to the second-line drugs is essential for early initiation of appropriate anti-tubercular treatment regimen among multi-drug tuberculosis (MDR-TB). In this study, we applied a multiplex allele-specific PCR (MAS-PCR) to identify the mutations on codons 90 and 94 of gyrA and nucleotide 1401 of rrs for detecting ofloxacin (OFX) and kanamycin (KAN) resistance in 139 MDR-TB isolates from...

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PMID: 29050755
DOI: 10.1016/j.tube.2017.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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