Article
Simultaneous detection of isoniazid, rifampin, and ethambutol resistance of Mycobacterium tuberculosis by a single multiplex allele-specific polymerase chain reaction (PCR) assay.
Diagnostic microbiology and infectious disease - 1 Nov 2005
Yang Zhenhua, Durmaz Riza, Yang Dong, Gunal Selami, Zhang Lixin, Foxman Betsy, Sanic Ahmet, Marrs Carl F
Abstract excerpt
Prompt detection of drug resistance of Mycobacterium tuberculosis is essential for effective control of tuberculosis (TB). We developed a multiplex allele-specific polymerase chain reaction (MAS-PCR) that detects the most commonly observed isoniazid (INH), rifampin (RIF), and ethambutol resistance-associated mutations in a single assay. The usefulness of the newly developed method was evaluated with 174 clinical...
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