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Article

Age-related changes in the mitochondria of human mural granulosa cells

28 Sept 2017

Abstract excerpt

STUDY QUESTION: What changes in the mitochondria of human mural granulosa cells (mGCs) with maternal aging? SUMMARY ANSWER: The mitochondrial membrane potential (MMP) and the ability of oxidative phosphorylation (OXPHOS) of mGCs declines with reproductive aging, accompanied with more abnormal mitochondria. WHAT IS KNOWN ALREADY: Mitochondria play an important role in the dialogue between the mGCs and oocytes....

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PMID: 29045673
DOI: 10.1093/humrep/dex309

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