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A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever

18 Oct 2017

Abstract excerpt

Lassa virus (LASV) is an ambisense RNA virus in the Arenaviridae family and is the etiological agent of Lassa fever, a severe hemorrhagic disease endemic to West and Central Africa.Citation1,2 There are no US Food and Drug Administration (FDA)-licensed vaccines available to prevent Lassa fever.Citation1,2 in our previous studies, we developed a gene-optimized DNA vaccine that encodes the glycoprotein precursor...

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PMID: 29045192
DOI: 10.1080/21645515.2017.1356500

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