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MiR-340 Reduces the Accumulation of Amyloid-β Through Targeting BACE1 (β-site Amyloid Precursor Protein Cleaving Enzyme 1) in Alzheimer’s Disease

20 Jan 2020

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is the most common neurodegenerative disease, and the accumulation of amyloid-β is the initial process in AD. MicroRNAs (miRNAs) are widely known as key regulators of the accumulation of amyloid-β in AD. This study analyzed the potential effects and possible internal mechanisms of miR-340 on AD. METHODS: The expression of miR-340 in senescence-accelerated mouse prone-8 (SAMP8)...

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PMID: 31957613
DOI: 10.2174/1567202617666200117103931

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