Article
Comparison of constitutive and thiabendazole-induced expression of five cytochrome P450 genes in fourth-stage larvae of Haemonchus contortus isolates with different drug susceptibility identifies one gene with high constitutive expression in a multi-resistant isolate.
International journal for parasitology. Drugs and drug resistance - 1 Dec 2017
Yilmaz Esra, Ramünke Sabrina, Demeler Janina, Krücken Jürgen
Abstract excerpt
Benzimidazoles (BZs) remain amongst the most widely used anthelmintic drug classes against gastro-intestinal nematode infections, although their efficacy is increasingly compromised by resistance. The primary underlying mechanisms for BZ resistance are single-nucleotide polymorphisms (SNPs) in the isotype 1 β-tubulin gene causing the substitutions F167Y, E198A or F200Y. However, resistance is believed to be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.