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Article

MCPH1 patient cells exhibit delayed release from DNA damage-induced G2/M checkpoint arrest.

Cell cycle (Georgetown, Tex.) - 15 Dec 2010

Gavvovidis Ioannis, Pöhlmann Charlotte, Marchal Juan Alberto, Stumm Markus, Yamashita Daisuke, Hirano Tatsuya, Schindler Detlev, Neitzel Heidemarie, Trimborn Marc

Abstract excerpt

Mutations in the MCPH1 gene cause primary microcephaly associated with a unique cellular phenotype of misregulated chromosome condensation. The encoded protein contains three BRCT domains, and accumulating data show that MCPH1 is involved in the DNA damage response. However, most of this evidence has been generated by experiments using RNA interference (RNAi) and cells from non-human model organisms. Here, we...

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Source

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Identifiers

PMID: 21150325
DOI: 10.4161/cc.9.24.14157
PMCID: PMC3047812

Genes

MCPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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MCPH1 patient cells exhibit delayed release from DNA damage-induced G2/M checkpoint arrest.PMID 21150325Read ↗

A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.Semantic proximity Read ↗

Chromosome structure deficiencies in MCPH1 syndrome.Semantic proximity Read ↗

MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.Semantic proximity Read ↗

MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis.Semantic proximity Read ↗

The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.Semantic proximity Read ↗

MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II.Semantic proximity Read ↗

Misregulated chromosome condensation in MCPH1 primary microcephaly is mediated by condensin II.Semantic proximity Read ↗

Microcephalin/MCPH1 Associates with the Condensin II Complex to Function in Homologous Recombination RepairSemantic proximity Read ↗

SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation.Semantic proximity Read ↗

Multifaceted Microcephaly-Related Gene MCPH1.Semantic proximity Read ↗

The first missense alteration in the MCPH1 gene causes autosomal recessive microcephaly with an extremely mild cellular and clinical phenotype.Semantic proximity Read ↗

Microcephalin: A Causal Link Between Impaired Damage Response Signalling and MicrocephalySemantic proximity Read ↗

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