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Article

MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II.

The Journal of cell biology - 19 Sept 2011

Yamashita Daisuke, Shintomi Keishi, Ono Takao, Gavvovidis Ioannis, Schindler Detlev, Neitzel Heidemarie, Trimborn Marc, Hirano Tatsuya

Abstract excerpt

Mutations in human MCPH1 (hMCPH1) cause primary microcephaly, which is characterized by a marked reduction of brain size. Interestingly, hMCPH1 mutant patient cells display unique cellular phenotypes, including premature chromosome condensation (PCC), in G2 phase. To test whether hMCPH1 might directly participate in the regulation of chromosome condensation and, if so, how, we developed a cell-free assay using...

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Identifiers

PMID: 21911480
DOI: 10.1083/jcb.201106141
PMCID: PMC3207293

Genes

MCPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II.PMID 21911480Read ↗

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