Article
MicroRNA-532 protects the heart in acute myocardial infarction, and represses prss23, a positive regulator of endothelial-to-mesenchymal transition.
Cardiovascular research - 1 Nov 2017
Bayoumi Ahmed S, Teoh Jian-Peng, Aonuma Tatsuya, Yuan Zhize, Ruan Xiaofen, Tang Yaoliang, Su Huabo, Weintraub Neal L, Kim Il-Man
Abstract excerpt
AIMS: Acute myocardial infarction (MI) leads to cardiac remodelling and development of heart failure. Insufficient myocardial capillary density after MI is considered a critical determinant of this process. MicroRNAs (miRs), negative regulators of gene expression, have emerged as important players in MI. We previously showed that miR-532-5p (miR-532) is up-regulated by the β-arrestin-biased β-adrenergic receptor...
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