Pathogenic Mechanisms of Bicuspid Aortic Valve Aortopathy

Abstract excerpt

Bicuspid aortic valve (BAV) is the most common congenital valvular defect and is associated with ascending aortic dilation (AAD) in a quarter of patients. AAD has been ascribed to both to the hemodynamic consequences of normally- functioning and abnormal BAV morphology, and to the effect of rare and common genetic variation upon function of the ascending aortic media. AAD takes manifests in two overall and...

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