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Dual-Target Inhibitors Based on PARP1: New Trend in the Development of Anticancer Research

8 Mar 2022

Abstract excerpt

PARP1 is a hot target, and its inhibitors have been approved for cancer therapy. However, some undesirable properties restrict the application of PARP1 inhibitors, including drug resistance, side effects and low efficiency. For multifactorial diseases, dual-target drugs have exhibited excellent synergistic effects, such as reduced drug resistance, low side effects and high therapeutic efficacy, by simultaneously...

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PMID: 35257598
DOI: 10.4155/fmc-2021-0292

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