Article
Radiofrequency ablation for locally advanced pancreatic cancer: SMAD4 analysis segregates a responsive subgroup of patients.
Langenbeck's archives of surgery - 1 Mar 2018
Paiella Salvatore, Malleo Giuseppe, Cataldo Ivana, Gasparini Clizia, De Pastena Matteo, De Marchi Giulia, Marchegiani Giovanni, Rusev Borislav, Scarpa Aldo, Girelli Roberto, Giardino Alessandro, Frigerio Isabella, D'Onofrio Mirko, Secchettin Erica, Bassi Claudio, Salvia Roberto
Abstract excerpt
PURPOSE: SMAD4 mutational status correlates with pancreatic ductal adenocarcinoma (PDAC) failure pattern. We investigated in a subset of locally advanced patients submitted to radiofrequency ablation (RFA) whether the assessment of SMAD4 status is a useful way to select the patients. METHODS: Clinical, radiological, and follow-up details of patients submitted to RFA for locally advanced pancreatic cancer (LAPC),...
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