Peripheral blood micro RNA and VEGFA mRNA changes following electroconvulsive therapy: implications for psychotic depression

Abstract excerpt

OBJECTIVE: MicroRNAs are short, non-coding molecules that regulate gene expression. Here, we investigate the role of microRNAs in depression and electroconvulsive therapy (ECT). METHODS: We performed three studies: a deep sequencing discovery-phase study of miRNA changes in whole blood following ECT (n = 16), followed by a validation study in a separate cohort of patients pre-/post-ECT (n = 37) and matched...

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