Article
Mapping allele with resolved carrier status of Robertsonian and reciprocal translocation in human preimplantation embryos.
Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 2017
Xu Jiawei, Zhang Zhen, Niu Wenbin, Yang Qingling, Yao Guidong, Shi Senlin, Jin Haixia, Song Wenyan, Chen Lei, Zhang Xiangyang, Guo Yihong, Su Yingchun, Hu Linli, Zhai Jun, Zhang Yile, Dong Fangli, Gao Yumei, Li Wenhui, Bo Shiping, Hu Mintao, Ren Jun, Huang Lei, Lu Sijia, Xie X Sunney, Sun Yingpu
Abstract excerpt
Reciprocal translocations (RecT) and Robertsonian translocations (RobT) are among the most common chromosomal abnormalities that cause infertility and birth defects. Preimplantation genetic testing for aneuploidy using comprehensive chromosome screening for in vitro fertilization enables embryo selection with balanced chromosomal ploidy; however, it is normally unable to determine whether an embryo is a...
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