Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

25 Sept 2017

Abstract excerpt

It has been known for some time that atherosclerotic lesions preferentially develop in areas exposed to low SS and are characterized by a proinflammatory, apoptotic, and senescent endothelial phenotype. Conversely, areas exposed to high SS are protected from plaque development, but the mechanisms have remained elusive. Autophagy is a protective mechanism that allows recycling of defective organelles and proteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Extracellular vesicles in disease

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28973855
DOI: 10.1073/pnas.1702223114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flowPMID 28973855Read ↗

Autophagy in vascular endothelial cellsSemantic proximity Read ↗

Elucidating the crosstalk between endothelial-to-mesenchymal transition (EndoMT) and endothelial autophagy in the pathogenesis of atherosclerosis.Semantic proximity Read ↗

Oxidative Stress Triggers Defective Autophagy in Endothelial Cells: Role in Atherothrombosis DevelopmentSemantic proximity Read ↗

Autophagy in cardiovascular biologySemantic proximity Read ↗

Implications of autophagy for vascular smooth muscle cell function and plasticitySemantic proximity Read ↗

Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular DiseaseSemantic proximity Read ↗

Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.Semantic proximity Read ↗

eIF2α mediated integrated stress response connects multiple intracellular signaling to reprogram vascular smooth muscle cell fate in carotid plaquesSemantic proximity Read ↗

Shear Stress in Autophagy and Its Possible Mechanisms in the Process of AtherosclerosisSemantic proximity Read ↗

Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cellsSemantic proximity Read ↗

Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression.Semantic proximity Read ↗

Defective Autophagy in Atherosclerosis: To Die or to Senesce?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.