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Article

Identification and Management of TP53 Gene Carriers Detected Through Multigene Panel Testing.

Southern medical journal - 1 Oct 2017

Pal Tuya, Brzosowicz Jennifer, Valladares Ailyn, Wiesner Georgia L, Laronga Christine

Abstract excerpt

OBJECTIVES: The increasing use of multigene panel tests may reveal an unexpected pathogenic variant in the tumor protein p53 (TP53) gene among individuals who do not meet clinical criteria for Li-Fraumeni syndrome (LFS). Among a registry-based sample of individuals with a pathogenic (P) or likely pathogenic (LP) variant in TP53, we sought to characterize the original clinical context in which genetic testing was...

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Identifiers

PMID: 28973705
DOI: 10.14423/SMJ.0000000000000711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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