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Article

Downregulation of DNMT3A by miR-708-5p Inhibits Lung Cancer Stem Cell-like Phenotypes through Repressing Wnt/β-catenin Signaling.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2018

Liu Tianchi, Wu Xiaoping, Chen Tong, Luo Zewei, Hu Xiaohua

Abstract excerpt

Purpose: Lung cancer is the leading cause of cancer-related death in the world, and emerging evidences suggest that lung cancer stem cells (CSC) are associated with its poor prognosis, tumor recurrence, and therapy resistance. Here we reveal a novel role for miR-708-5p in inhibiting lung CSC-like features.Experimental Design: Phenotypic effects of miR-708-5p on the lung CSC-like properties were examined by in...

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PMID: 28972040
DOI: 10.1158/1078-0432.CCR-17-1169

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CDH1

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