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Article

Esophageal Adenocarcinoma-Derived Extracellular Vesicle MicroRNAs Induce a Neoplastic Phenotype in Gastric Organoids.

Neoplasia (New York, N.Y.) - 1 Nov 2017

Ke Xiquan, Yan Rong, Sun Zhenguo, Cheng Yulan, Meltzer Amy, Lu Nonghua, Shu Xu, Wang Zhe, Huang Binbin, Liu Xi, Wang Zhixiong, Song Jee Hoon, Ng Christopher K, Ibrahim Sariat, Abraham John M, Shin Eun Ji, He Shuixiang, Meltzer Stephen J

Abstract excerpt

There have been no reports describing the effects of cancer cell-derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated the proneoplastic effects of esophageal adenocarcinoma (EAC)-derived EVs on gastric organoids (gastroids) and elucidated molecular mechanisms underlying these effects. EVs were identified using PKH-67 staining. Morphologic changes, Ki-67...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28968550
DOI: 10.1016/j.neo.2017.06.007
PMCID: PMC5633352

Genes

AIFM3
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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