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Article

Detection of azole-susceptible and azole-resistant Aspergillus coinfection by cyp51A PCR amplicon melting curve analysis.

The Journal of antimicrobial chemotherapy - 1 Nov 2017

Schauwvlieghe A F A D, Vonk A G, Buddingh E P, Hoek R A S, Dalm V A, Klaassen C H W, Rijnders B J A

Abstract excerpt

BACKGROUND: The AsperGenius® assay is a multiplex real-time PCR test that allows the simultaneous detection of Aspergillus species and identification of the most common mutations in the Aspergillus fumigatus cyp51A gene conferring resistance (TR34/L98H and TR46/T289A/Y121F) by using melting curve analysis. Mixed infections with azole-resistant and susceptible A. fumigatus have rarely been described. METHODS: The...

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PMID: 28961889
DOI: 10.1093/jac/dkx262

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