Article
Increased autophagy contributes to the inflammatory phenotype of juvenile idiopathic arthritis synovial fluid T cells.
Rheumatology (Oxford, England) - 1 Oct 2017
Peeters Janneke G C, de Graeff Nienke, Lotz Martin, Albani Salvatore, de Roock Sytze, van Loosdregt Jorg
Abstract excerpt
Objectives: JIA is an autoimmune disease involving disturbed T-cell homeostasis, marked by highly activated effector T cells. Autophagy, a lysosomal degradation pathway, is crucial for maintaining cellular homeostasis by regulating the survival, differentiation and function of a large variety of cells, including T cells. The aim of this study was to examine the rate of autophagy in JIA T cells and to investigate...
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