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High rate of adaptation of mammalian proteins that interact with Plasmodium and related parasites

28 Sept 2017

Abstract excerpt

Plasmodium parasites, along with their Piroplasm relatives, have caused malaria-like illnesses in terrestrial mammals for millions of years.Several Plasmodium-protective alleles have recently evolved in human populations, but little is known about host adaptation to blood parasites over deeper evolutionary timescales.In this work, we analyze mammalian adaptation in ~500 Plasmodium-or Piroplasm-interacting...

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PMID: 28957326
DOI: 10.1371/journal.pgen.1007023

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