Article
The amino terminus of Epstein-Barr virus glycoprotein gH is important for fusion with epithelial and B cells.
Journal of virology - 1 Oct 2005
Omerović Jasmina, Lev Lori, Longnecker Richard
Abstract excerpt
Epstein-Barr virus (EBV) infects B lymphocytes and epithelial cells. While the glycoproteins required for entry into these two cell types differ, the gH/gL glycoprotein complex is essential for entry into both epithelial and B cells. Analysis of gH protein sequences from three gammaherpesviruses (EBV, marmoset, and rhesus) revealed a potential coiled-coil domain in the N terminus. Four leucines located in this...
Topics
- Amino Acid Substitution
- Animals
- B-Lymphocytes
- Cell Line
- Cell Membrane
- Cricetinae
- Epithelial Cells
- Glycoproteins
- Herpesvirus 4, Human
- Humans
- Membrane Fusion
- Membrane Glycoproteins
- Molecular Chaperones
- Mutagenesis, Site-Directed
- Mutation