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Article

Cardiac, mandibular and thymic phenotypical association indicates that cranial neural crest underlies bicuspid aortic valve formation in hamsters.

PloS one - 1 Jan 2017

Martínez-Vargas Jessica, Ventura Jacint, Machuca Ángela, Muñoz-Muñoz Francesc, Fernández María Carmen, Soto-Navarrete María Teresa, Durán Ana Carmen, Fernández Borja

Abstract excerpt

Bicuspid aortic valve (BAV) is the most prevalent human congenital cardiac malformation. It may appear isolated, associated with other cardiovascular malformations, or forming part of syndromes. Cranial neural crest (NC) defects are supposed to be the cause of the spectrum of disorders associated with syndromic BAV. Experimental studies with an inbred hamster model of isolated BAV showed that alterations in the...

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Identifiers

PMID: 28953926
DOI: 10.1371/journal.pone.0183556
PMCID: PMC5617148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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