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Article

Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers.

PloS one - 1 Jan 2017

Lander Julie M, Supp Dorothy M, He Hua, Martin Lisa J, Chen Xiaoting, Weirauch Matthew T, Boyce Steven T, Kopan Raphael

Abstract excerpt

To identify putative gene regulatory regions that respond to epidermal injury, we mapped chromatin dynamics in a stratified human epidermis during barrier maturation and disruption. Engineered skin substitutes (ESS) cultured at the air-liquid interface were used as a model of developing human epidermis with incomplete barrier formation. The epidermal barrier stabilized following engraftment onto immunocompromised...

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PMID: 28953906
DOI: 10.1371/journal.pone.0184500
PMCID: PMC5617145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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