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Article

HIF-2alpha: Achilles' heel of pseudohypoxic subtype paraganglioma and other related conditions.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2017

Tella Sri Harsha, Taïeb David, Pacak Karel

Abstract excerpt

Paragangliomas (PGLs) belong to the most hereditary endocrine tumours. The existence of mutated HIF2A in these tumours, the role of oncometabolites on HIFs stabilisation and a recent concept proposing how hereditary PGLs converge on the hypoxia-signalling pathway, brought solid evidence of the existence of PGL hypoxiom. Hypoxia-inducible factor 2alpha (HIF-2α) antagonists -PT2385, and PT2399 have been shown to...

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Identifiers

PMID: 28946040
DOI: 10.1016/j.ejca.2017.08.023
PMCID: PMC6287501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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