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Article

Women who carry a fragile X premutation are biologically older than noncarriers as measured by telomere length.

American journal of medical genetics. Part A - 1 Nov 2017

Albizua Igor, Rambo-Martin Benjamin L, Allen Emily G, He Weiya, Amin Ashima S, Sherman Stephanie L

Abstract excerpt

Women who carry a fragile X premutation, defined as having 55-200 unmethylated CGG repeats in the 5' UTR of the X-linked FMR1 gene, have a 20-fold increased risk for primary ovarian insufficiency (FXPOI). We tested the hypothesis that women with a premutation + FXPOI have shorter telomeres than those without FXPOI because they are "biologically older." Using linear regression, we found that women carrying a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28941155
DOI: 10.1002/ajmg.a.38476
PMCID: PMC5650511

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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