Article
Strain-dependent neutralization reveals antigenic variation of human parechovirus 3.
Scientific reports - 21 Sept 2017
Karelehto Eveliina, van der Sanden Sabine, Geraets James A, Domanska Aušra, van der Linden Lonneke, Hoogendoorn Dionne, Koen Gerrit, van Eijk Hetty, Shakeel Shabih, Beaumont Tim, de Jong Menno, Pajkrt Dasja, Butcher Sarah J, Wolthers Katja C
Abstract excerpt
Human parechovirus 3 (HPeV3), a member of the Picornavirus family, is frequently detected worldwide. However, the observed seropositivity rates for HPeV3 neutralizing antibodies (nAbs) vary from high in Japan to low in the Netherlands and Finland. To study if this can be explained by technical differences or antigenic diversity among HPeV3 strains included in the serological studies, we determined the...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Neutralizing
- Antigenic Variation
- Capsid Proteins
- Humans
- Immune Sera
- Japan
- Mutation
- Netherlands
- Neutralization Tests
- Parechovirus
- Picornaviridae Infections