Article
Specific cell tropism and neutralization of human parechovirus types 1 and 3: implications for pathogenesis and therapy development.
The Journal of general virology - 1 Nov 2012
Westerhuis Brenda M, Koen Gerrit, Wildenbeest Joanne G, Pajkrt Dasja, de Jong Menno D, Benschop Kimberley S M, Wolthers Katja C
Abstract excerpt
Human parechoviruses (HPeVs) are picornaviruses frequently infecting humans. While HPeV1 is associated with mild disease, HPeV3 is the cause of neonatal sepsis and meningitis. To test whether in vitro replication kinetics of HPeV1 and HPeV3 could be related to pathogenicity, HPeV1 and HPeV3 strains isolated from patients were cultured on cell lines of gastrointestinal, respiratory and neural origin, and...
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