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Article

Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.

Human molecular genetics - 15 Sept 2017

Berthon A, Faucz F R, Espiard S, Drougat L, Bertherat J, Stratakis C A

Abstract excerpt

Inactivating mutations in the Armadillo repeat-containing 5 (ARMC5) gene have recently been discovered in primary macronodular adrenal hyperplasia (PMAH), a cause of Cushing syndrome. Biallelic ARMC5 inactivation in PMAH suggested that ARMC5 may have tumor suppressor functions in the adrenal cortex. We generated and characterized a new mouse model of Armc5 deficiency. Almost all Armc5 knockout mice died during...

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Source

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Identifiers

PMID: 28911199
DOI: 10.1093/hmg/ddx235
PMCID: PMC6074838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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