Article
Distinct Phenotypes of Smokers with Fixed Airflow Limitation Identified by Cluster Analysis of Severe Asthma.
Annals of the American Thoracic Society - 1 Jan 2018
Konno Satoshi, Taniguchi Natsuko, Makita Hironi, Nakamaru Yuji, Shimizu Kaoruko, Shijubo Noriharu, Fuke Satoshi, Takeyabu Kimihiro, Oguri Mitsuru, Kimura Hirokazu, Maeda Yukiko, Suzuki Masaru, Nagai Katsura, Ito Yoichi M, Wenzel Sally E, Nishimura Masaharu
Abstract excerpt
RATIONALE: Smoking may have multifactorial effects on asthma phenotypes, particularly in severe asthma. Cluster analysis has been applied to explore novel phenotypes, which are not based on any a priori hypotheses. OBJECTIVES: To explore novel severe asthma phenotypes by cluster analysis when including smoking patients with asthma. METHODS: We recruited a total of 127 subjects with severe asthma, including 59...
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